depression Archives | ��ϳԹ��Դ

Fish oil may increase CTE risk after brain injury

Nick Wurm — Tue, 07 Apr 2026 11:30:07 +0000

Neurodegenerative conditions like chronic traumatic encephalopathy (CTE) are often called a silent pandemic. Even so-called “mild” concussions, like those sustained in contact sports, may have a cascading effect over time. CTE symptoms such as mood swings, memory loss, and depression may not appear for decades. A new study suggests one common dietary supplement may, in...

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Deciphering brain diseases with click chemistry

Communications Department — Tue, 18 Feb 2025 12:30:53 +0000

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Ketamine: From club drug to antidepressant?

Samuel Diamond — Fri, 14 Feb 2025 16:00:46 +0000

AI generated voice Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat conditions from post-traumatic stress disorder to depression. “The practice is not without controversy,” notes ��ϳԹ��Դ (CSHL)...

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This protein does “The Twist”

Luis Sandoval — Wed, 31 Jul 2024 15:00:56 +0000

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These...

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At the Lab Episode 2: Molecular puppetry

Communications Department — Tue, 09 Apr 2024 11:30:36 +0000

It’s easy to think of your brain as your body’s puppet master. This week At the Lab, we speak with CSHL Professor Hiro Furukawa, who studies a part of the brain that actually does work a lot like a puppeteer. Hear how Furukawa figured out the puppet master’s routine. And find out what that might...

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Mapping brain disorder therapeutics at work

Communications Department — Fri, 29 Jul 2022 16:00:19 +0000

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Picky proteins: A new angle for brain disorder therapeutics

Communications Department — Fri, 20 May 2022 11:30:48 +0000

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Reward and punishment take similar paths in the mouse brain

Jennifer Michalowski — Tue, 15 Sep 2020 15:00:21 +0000

Allen Brain Atlas, Mouse Brain Connectivity Atlas, Dorsal Striatum" data-description="" />��ϳԹ��Դ (CSHL) scientists have discovered neurons in the mouse brain that help an animal learn to avoid negative experiences. The cells reside in a part of the brain involved in regulating the motivations that influence behavior. Previously, this part of the brain, known as the striosome, was thought to be dedicated to...

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Brain receptor pulls open electrical gate like a puppet master

Communications Department — Tue, 30 Jun 2020 15:09:08 +0000

For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals. Critical for brain development and function, the receptor converts chemical messages between cells into electrical signals within a neuron. The...

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New look at odd holes involved in taste, Alzheimer’s, asthma

Brian Stallard — Mon, 27 Jan 2020 16:00:39 +0000

Many cells are covered with mysterious large holes, pores that have been associated with the sense of taste as well as Alzheimer’s disease, depression, and even asthma. Knowing the structure of these varied holes will help researchers better understand this range of associations and provide a blueprint for developing new therapies. “One of the most...

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How the brain balances pleasure and pain

Jennifer Michalowski — Tue, 31 Dec 2019 16:00:47 +0000

As our brains take in information about the world and use it to steer our actions, two key principles guide our choices: seek pleasure and avoid pain. Researchers at ��ϳԹ��Դ (CSHL) have zeroed in on an information-processing hub in the brains of mice to discover how neurons there divide the labor to...

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Interview with a neuroscientist

Charlotte Hu — Fri, 31 May 2019 13:18:26 +0000

Comprised of a M.C. Escher-esque network of pathways, the brain is a maze of chaotic proportions. In its full-functioning glory, the brain helps us move, think, dream, and create. It’s a beautiful marvel of evolution that coordinates and translates messages from cells into emotions, memories, and actions. But what happens in the brain when its...

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Brain, interrupted

Charlotte Hu — Fri, 31 May 2019 13:09:13 +0000

{“questions”:{“nk5k0”:{“id”:”nk5k0″,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:”Edvard Munch ‘The Scream'”,”image”:”https:\/\/www.cshl.edu\/wp-content\/uploads\/2019\/05\/The_Scream-Edvard-Munch.jpg”,”imageId”:”28655″,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”In a normal brain, we have a programmed response to a threatening situation. In a brain riddled with anxiety, that normal program is overriden. These reactionary responses are processed in a part of the brain that codes emotions, called the:”,”desc”:”The amygdala is the brain\u2019s seat of emotion, otherwise known as the alarm...

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How the brain hears and fears

Jennifer Michalowski — Wed, 05 Dec 2018 10:00:12 +0000

Cold Spring Harbor, NY — How is it that a sound can send a chill down your spine? By observing individual brain cells of mice, scientists at ��ϳԹ��Դ (CSHL) are understanding how a sound can incite fear. Investigator Bo Li focuses on a part of the mouse brain called the amygdala where...

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How key brain receptor works in hostile conditions

Communications Department — Wed, 09 May 2018 19:38:59 +0000

Cold Spring Harbor, NY — During a stroke or an epileptic seizure, neurons in affected parts of the brain fire at an abnormally rapid rate. One byproduct of this condition is that the pH of the brain drops markedly, rendering the local environment inhospitably acidic. Using a powerful microscopy method called cryo-EM, biologists at Cold...

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Portrait of a Neuroscience Powerhouse

Peter Tarr — Fri, 27 Apr 2018 16:07:30 +0000

At noon every Tuesday from September through June, scenes from a revolution in neuroscience are playing out at ��ϳԹ��Դ. Week after week, over 100 scientists cram themselves into a ground-floor meeting room in the Beckman Laboratory. It’s standing-room only as everyone in the Neuroscience Program settles in to hear details of the...

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Detailed images of NMDA receptor show how zinc and a potential drug affect its function

Peter Tarr — Thu, 01 Dec 2016 12:00:26 +0000

Drugs precisely targeting portions of this receptor may have applications in Alzheimer’s, depression and schizophrenia Cold Spring Harbor, NY — The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is brought to light by...

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Was it better or worse than you expected? Your basal ganglia know – so you can act accordingly

Peter Tarr — Wed, 21 Sep 2016 13:01:44 +0000

Identifying a neural circuit that processes evaluations, with implications for understanding depression Cold Spring Harbor, NY — You make reservations at a restaurant, expecting the food to be good. If the meal turns out to be superb—even better than expected—that’s information you will want to remember, so you can go back again. The reverse applies...

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Dealing with stress—to cope or to quit?

Communications Department — Tue, 27 May 2014 22:10:00 +0000

Researchers identify neurons that determine whether an individual will be depressed or resilient Cold Spring Harbor, NY — We all deal with stress differently. For many of us, stress is a great motivator, spurring a renewed sense of vigor to solve life’s problems. But for others, stress triggers depression. We become overwhelmed, paralyzed by hopelessness...

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Team demonstrates power of precision medicine in successful treatment of patient with disabling OCD

Peter Tarr — Thu, 03 Oct 2013 08:00:50 +0000

Cold Spring Harbor, NY — A multidisciplinary team led by a geneticist and psychiatrist from ��ϳԹ��Դ’s (CSHL) Stanley Institute for Cognitive Genomics today publish a paper providing a glimpse of both the tremendous power and the current limitations of what is sometimes called “precision medicine.” Precision medicine is an approach to diagnosis...

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