CRISPR Archives | ��ϳԹ��Դ

CRISPR primes goldenberry for fruit bowl fame

Margaret Osborne — Fri, 12 Dec 2025 12:30:59 +0000

Since the dawn of agriculture around 10,000 years ago, our ancestors have saved seeds from the tastiest, largest, and most resilient crops to plant in the following season. Today, most fruits and vegetables we buy are the result of hundreds to thousands of years of selective breeding. Now, ��ϳԹ��Դ (CSHL) plant biologists...

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AI offers ‘roadmap’ to plant genetics

Margaret Osborne — Mon, 08 Dec 2025 12:30:47 +0000

As global temperatures rise, ��ϳԹ��Դ (CSHL) scientists work to grow stronger, more resilient crops. Yet, this process is challenging. Plants often have several related genes that control desirable traits, such as size or drought resistance. Finding genes with overlapping functions, or “redundant genes,” is a near-impossible scavenger hunt. “Most of the time,...

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The world’s first personalized gene therapy

Samuel Diamond — Wed, 03 Dec 2025 12:30:58 +0000

How does science make life better? Here’s one example spanning eons. There’s an adaptive immune system called CRISPR that has existed in bacteria for billions of years. Thanks to fundamental biology research, it is now being used to discover and develop powerful new forms of medicine. Just this year, the first personalized CRISPR gene-editing therapy...

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Enter the CRISPR frontier

Communications Department — Mon, 08 Sep 2025 11:30:33 +0000

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The CRISPR revolution continues

Nick Wurm — Tue, 12 Aug 2025 18:13:47 +0000

CRISPR-Cas9 gene editing revolutionized biological and biomedical research virtually overnight. The versatile tool has been used to improve crop yields and cure previously uncurable conditions like sickle cell anemia. In May 2025, the Nobel Prize-winning technology brought about another major biomedical breakthrough, as Kiran Musunuru and Rebecca Ahrens-Nicklas introduced the first personalized CRISPR gene editing...

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At the Lab: Science for lovers

Communications Department — Tue, 15 Apr 2025 11:30:27 +0000

��ϳԹ��Դ Professor Zach Lippman’s research in plant prickles resulted in one of CSHL’s most publicized discoveries of 2024. It also gets at the very heart of what motivates basic bioscience research here At the Lab. You’ve read about it in The New York Times and seen it on CNN. Now, hear all...

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CRISPR manipulates plants’ flower powers

Margaret Osborne — Wed, 19 Feb 2025 17:00:49 +0000

AI generated voice with Zachary Lippman’s actual voice Humans have appreciated the beauty of flowers for centuries. Yet, flowers aren’t just aesthetically pleasing. They also play a crucial role in plant reproduction. In all plants, a well-studied gene with a curious name, Unusual Floral Organs (UFO), orchestrates the flowering process. UFO expression hinges on another...

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Flipping cancer’s off switch

Communications Department — Thu, 07 Nov 2024 12:30:54 +0000

If there’s one thing cancer knows, it’s growth. Over the last two decades, scientists have observed that many cancers progress by activating a set of proteins called YAP and TAZ, which control cell growth and organ size. When left uncontrolled, YAP/TAZ can lead to tumor formation. So, if you’re looking for new drug targets, why...

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CSHL grad student wins International Birnstiel Award

Nick Wurm — Mon, 23 Sep 2024 11:30:55 +0000

��ϳԹ��Դ (CSHL) School of Biological Sciences (SBS) graduate Shushan Toneyan has won the 2024 International Birnstiel Award for Doctoral Research in Molecular Life Sciences. A member of the SBS Class of 2024, Toneyan is one of six recipients of this year’s award. She received it in recognition of her thesis research in...

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Is CREME AI’s answer to CRISPR?

Luis Sandoval — Mon, 16 Sep 2024 09:00:02 +0000

Imagine you’re looking at millions upon millions of mysterious genetic mutations. With CRISPR gene-editing technology, a select few of these mutations might have therapeutic potential. However, proving it would mean many thousands of hours of lab work. Just figuring out which ones are worth exploring further would take a lot of time and money. But...

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At the Lab Episode 23: Cured with CRISPR

Communications Department — Tue, 10 Sep 2024 11:30:08 +0000

In 2019, Victoria Gray became the first person to be cured of sickle cell disease thanks to CRISPR gene-editing technology. Five years later, a diverse audience of Long Island locals came together At the Lab to hear Gray speak with two ��ϳԹ��Դ DNA Learning Center alumni and a panel of experts, including...

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The promise of genetics to cure disease

Communications Department — Thu, 05 Sep 2024 11:30:19 +0000

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At the Lab Episode 22: Outmuscling cancer

Communications Department — Tue, 03 Sep 2024 11:30:30 +0000

In 2014, experts from across the country came together at CSHL’s Banbury Center to discuss rhabdomyosarcoma (RMS), a tissue cancer mainly diagnosed in children. Now, CSHL Professor Christopher Vakoc could be at a turning point. You may have seen Vakoc on FOX. This week At the Lab, he brings us an RMS breakthrough 10 years...

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One Experiment: The devil in the greenhouse

Nick Wurm — Thu, 15 Aug 2024 11:30:47 +0000

Solanum atropurpureum, seen here. Image: Blaine Fitzgerald, Lippman lab" data-description="" />Tomatoes and potatoes have a lot of relatives. Their nightshade genus includes over 1,500 distinct species. But not all are as friendly as those beloved staple foods. Lurking amongst them is a prickly purple devil with a supervillainous moniker. Its name? Malevolence. Some plants just hate us. Malevolence is covered in sharp, 1-to-1.5-inch-long barbs—the largest...

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Every rose has its thorns … or does it?

Margaret Osborne — Thu, 01 Aug 2024 18:00:23 +0000

According to Greek mythology, red roses first appeared when Aphrodite pricked her foot on a thorn, spilling blood on a white rose. Since then, roses’ thorns have captured the imaginations of countless poets and forlorn lovers. But they aren’t the only plants with these dangerous protrusions, technically called prickles. Prickles have evolved independently in species...

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How to stop cancer cachexia? Start at the top

Nick Wurm — Mon, 08 Jul 2024 11:30:11 +0000

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes—like the body’s immune response—to grow and spread. When tumors elevate levels of an immune system molecule called Interleukin-6 (IL-6), it can cause severe brain dysfunction. In about 50%-80% of cancer patients, this leads to a lethal wasting disease called cachexia. “It’s a...

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CSHL to host first person cured of sickle cell

Communications Department — Fri, 28 Jun 2024 11:30:50 +0000

Sickle cell disease is a painful and debilitating genetic condition. It affects over 100,000 people in the U.S. and more than 20 million globally—most are Black or of African origin. Until recently, sickle cell was considered a lifelong disease. Then, in 2019, Victoria Gray became the first patient cured using CRISPR gene-editing technology. On July...

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Meet Xenopus, the African clawed frog

Luis Sandoval — Thu, 06 Jun 2024 11:30:41 +0000

Xenopus course at CSHL pose with the star of the course, the African clawed frog. Left to right: Rachel Miller, Peter Walentek, Lance Davidson, and Chenbei Chang." data-description="" />Sometimes, groundbreaking biomedical discoveries and technology can come from the strangest sources. A perfect example: Xenopus, the African clawed frog. It swims upside down. It’s see-through. And it makes an ideal test subject for studying genes that may cause or help cure diseases in humans. This year, scientists from around the globe once again descended...

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An evolutionary mystery 125 million years in the making

Luis Sandoval — Mon, 04 Mar 2024 19:00:44 +0000

Plant genomics has come a long way since ��ϳԹ��Դ (CSHL) helped sequence the first plant genome. But engineering the perfect crop is still, in many ways, a game of chance. Making the same DNA mutation in two different plants doesn’t always give us the crop traits we want. The question is why...

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You say genome editing, I say natural mutation

Luis Sandoval — Thu, 19 Oct 2023 18:00:46 +0000

For tens of thousands of years, evolution shaped tomatoes through natural mutations. Then, humans came along. For centuries, we’ve bred and cherry-picked tomatoes with our preferred traits. Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further. However, individual mutations, whether natural or engineered, don’t work alone. Each operates...

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CRISPR Archives | ���ϳԹ���Դ