core facility Archives | ��ϳԹ��Դ

Say Cheese3D: A new model for tracking facial expression

Samuel Diamond — Mon, 27 Apr 2026 09:00:05 +0000

Nature Neuroscience, Kyle Daruwalla, Irene Nozal Martin, and colleagues at ��ϳԹ��Դ introduce a computer vision system called Cheese3D. As senior author Helen Hou puts it, “Cheese3D turns the face into a window into the brain.” Image: Kyra Wang" data-description="A pencil drawing of three bats in different poses, overlaid with blue perspective grid lines." />Love, pain, joy, fear, desire: the full spectrum of emotion resides in facial expression. We grasp this almost intuitively. However, we still lack a quantifiable understanding of the nuanced relationship between the face and the brain. We haven’t yet found a way to precisely measure and reliably interpret the full complexity of facial expressions in...

The post Say Cheese3D: A new model for tracking facial expression appeared first on ��ϳԹ��Դ.

A Closer Look: CSHL’s Microscopy Core

Communications Department — Mon, 30 Mar 2026 11:30:28 +0000

The post A Closer Look: CSHL’s Microscopy Core appeared first on ��ϳԹ��Դ.

Immune response to cancer may cause brain disease

Samuel Diamond — Wed, 25 Mar 2026 16:00:01 +0000

Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated. If cancer arises from cellular mutation, why don’t we all have the disease all the time? Second: Severe autoimmune conditions like lupus and multiple sclerosis often strike without warning. No one knows...

The post Immune response to cancer may cause brain disease appeared first on ��ϳԹ��Դ.

Let’s get on pancreatic cancer’s nerves

Margaret Osborne — Mon, 09 Feb 2026 13:54:57 +0000

Pancreatic cancer has a lot of nerve. Notoriously tricky to detect, the disease also often resists traditional therapy. So, researchers are urgently looking for new ways to disrupt tumor formation. Though scientists know that the nervous system can help cancer spread, its role in the disease’s earliest stages remains unclear. “One phenomenon that is known...

The post Let’s get on pancreatic cancer’s nerves appeared first on ��ϳԹ��Դ.

New mass spec innovation could transform research

Nick Wurm — Tue, 06 Jan 2026 17:00:39 +0000

Weight says a lot. In the kitchen, it could mean cooking with too little or too much of an ingredient. For scientists, a molecule’s weight can help determine its makeup. This, in turn, can shed light on whether a potential drug is acting on the body or not working at all. Weight can even reveal...

The post New mass spec innovation could transform research appeared first on ��ϳԹ��Դ.

CSHL Animal Resources team recognized by NY State

Lisa Cruz — Tue, 25 Nov 2025 12:30:53 +0000

In 2023, the Viscardi Center (VC), a statewide nonprofit helping persons with disabilities find jobs and succeed in the workplace, assisted James Schaefer in securing a position at ��ϳԹ��Դ (CSHL) as a cage washer technician. Over the past two years, Schaefer has not only become proficient in his position but also begun training to...

The post CSHL Animal Resources team recognized by NY State appeared first on ��ϳԹ��Դ.

Shapeshifting cancers’ masters, unmasked

Jen A. Miller — Mon, 24 Nov 2025 12:30:01 +0000

Some tumors are almost impossible to treat. That’s especially true for carcinomas, which don’t behave like other malignancies. Some of these tumors act as shapeshifters and start to resemble cells from other organs of the human body, such as skin. This bizarre behavior presents a challenge for existing therapies. “The tumors are notoriously plastic in...

The post Shapeshifting cancers’ masters, unmasked appeared first on ��ϳԹ��Դ.

Uplands Farm: Grounds for discovery

Jennifer Michalowski — Wed, 12 Nov 2025 12:30:53 +0000

At first glance, Uplands Farm—12 carefully tended acres about a mile east of the ��ϳԹ��Դ (CSHL) campus—resembles farms you might have seen before. Orderly rows of corn dominate the fields, sharing space with sorghum, eggplants, and other crops. Three greenhouses shelter young plants, extending the growing season so they can flourish in...

The post Uplands Farm: Grounds for discovery appeared first on ��ϳԹ��Դ.

Breast cancer case study could inform clinical trials

Jen A. Miller — Mon, 10 Nov 2025 12:30:14 +0000

MALAT1 (pink) than the surrounding tissues." data-description="Fluorescent microscopy image showing clusters of blue and purple cells on a black background." />When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at ��ϳԹ��Դ (CSHL) have also been working on another kind of target. They’re studying a long non-coding RNA called...

The post Breast cancer case study could inform clinical trials appeared first on ��ϳԹ��Դ.

A doorstop for the brain’s electrical gates

Jennifer Michalowski — Wed, 29 Oct 2025 16:00:04 +0000

Nature, reveals the molecular mechanisms that keep the brain’s NMDA receptors fully or partially open." data-description="Image of NMDA receptors in different positions" />As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At ��ϳԹ��Դ (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell—and the molecular gatekeepers that help control them. CSHL structural biologist Hiro Furukawa studies NMDA receptors (NMDARs). These...

The post A doorstop for the brain’s electrical gates appeared first on ��ϳԹ��Դ.

Breast cancer discovery could help prevent recurrence

Margaret Osborne — Mon, 20 Oct 2025 11:30:07 +0000

Know someone who’s been diagnosed with breast cancer? There’s a good chance that person has received hormone therapy. Estrogen receptor-positive (ER+) breast cancers account for about 75 percent of cases. Hormone therapy is one of the most common and effective treatments. However, it’s far from a cure. Some ER+ tumors develop resistance. Many patients enter...

The post Breast cancer discovery could help prevent recurrence appeared first on ��ϳԹ��Դ.

You’ve never seen corn like this before

Margaret Osborne — Mon, 15 Sep 2025 11:30:56 +0000

Plant stem cells are crucial for the world’s food supply, animal feed, and fuel production. They lay the foundation for how plants grow. Yet, much about these mysterious building blocks remains unknown. Previous analyses have failed to locate many of the important genes that regulate how these cells function. Now, for the first time, Cold...

The post You’ve never seen corn like this before appeared first on ��ϳԹ��Դ.

It’s not you—it’s cancer

Jennifer Michalowski — Thu, 10 Apr 2025 18:00:51 +0000

AI generated voice with Tobias Janowitz’s actual voice Cancer ravages both body and mind. If you’ve ever lost loved ones to the disease, you might recognize the physical and emotional changes cancer patients often endure during their final months. They seem drained of strength and spirit. Even people who’ve maintained a positive outlook throughout their...

The post It’s not you—it’s cancer appeared first on ��ϳԹ��Դ.

In pancreatic cancer, a race against time

Samuel Diamond — Wed, 02 Apr 2025 04:05:05 +0000

Cancer Research and conducted with generous support from the Lustgarten Foundation, shows that inhibiting the FGFR2 and EGFR proteins in pancreatic cells can delay or even prevent tumor formation." data-description="" />AI generated voice with David Tuveson’s actual voice Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. ��ϳԹ��Դ (CSHL) Professor and...

The post In pancreatic cancer, a race against time appeared first on ��ϳԹ��Դ.

The food and fuel that farms itself

Nick Wurm — Tue, 01 Apr 2025 15:00:41 +0000

AI generated voice with Rob Martienssen’s and Evan Ernst’s actual voices Under the right conditions, duckweed essentially farms itself. Wastewater, ponds, puddles, swamps—you name it. If there’s enough sunlight and carbon dioxide, the aquatic plant can grow freely. But that’s not all that makes it intriguing. Packed inside duckweed’s tiny fronds is enormous potential as...

The post The food and fuel that farms itself appeared first on ��ϳԹ��Դ.

CSHL and global collaborators map Solanum pan-genome

Margaret Osborne — Wed, 05 Mar 2025 16:00:00 +0000

AI generated voice with Zachary Lippman’s actual voice About 75 percent of the world’s food comes from 12 plants. Scientists estimate up to 30,000 species are edible. Not only does this bottleneck jeopardize our food supply if a major crop is impacted by drought or disease—it also limits our choices at the grocery store. For...

The post CSHL and global collaborators map Solanum pan-genome appeared first on ��ϳԹ��Դ.

Ketamine: From club drug to antidepressant?

Samuel Diamond — Fri, 14 Feb 2025 16:00:46 +0000

AI generated voice Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat conditions from post-traumatic stress disorder to depression. “The practice is not without controversy,” notes ��ϳԹ��Դ (CSHL)...

The post Ketamine: From club drug to antidepressant? appeared first on ��ϳԹ��Դ.

Corn’s ancient ancestors are calling

Jen A. Miller — Thu, 06 Feb 2025 12:30:17 +0000

AI generated voice with Rob Martienssen’s and Thomas Gingeras’s actual voices The domestication of maize is one of the greatest examples of humankind’s impact on evolution. Early farmers’ pre-industrial plant breeding choices turned corn from a nearly inedible crop into the major global food source it is today. Now, ��ϳԹ��Դ Professors Rob...

The post Corn’s ancient ancestors are calling appeared first on ��ϳԹ��Դ.

A hearing aid for … your nose?

Nick Wurm — Thu, 30 Jan 2025 12:30:56 +0000

AI generated voice with Florin Albeanu’s actual voice Kaboom! The first time most of us hear the sound of an explosion is in the movies. Encountering the sound in the real world—even at a distance—has a profoundly different effect. Why? It’s all about context. How we react to sounds and other sensory stimuli depends on...

The post A hearing aid for … your nose? appeared first on ��ϳԹ��Դ.

Mixed signals: How the brain interprets social cues

Nick Wurm — Mon, 06 Jan 2025 12:30:45 +0000

AI generated voice with Stephen Shea’s actual voice Imagine you’re at a dinner party, but you can’t smell the food cooking or hear the dinner bell. Sounds like a dream, right? What if it wasn’t? “When we experience the world and interact with people, we use all our senses,” ��ϳԹ��Դ Professor Stephen...

The post Mixed signals: How the brain interprets social cues appeared first on ��ϳԹ��Դ.

core facility Archives | ���ϳԹ���Դ