cellular communication in cancer Archives | ��ϳԹ��Դ

Let’s get on pancreatic cancer’s nerves

Margaret Osborne — Mon, 09 Feb 2026 13:54:57 +0000

Pancreatic cancer has a lot of nerve. Notoriously tricky to detect, the disease also often resists traditional therapy. So, researchers are urgently looking for new ways to disrupt tumor formation. Though scientists know that the nervous system can help cancer spread, its role in the disease’s earliest stages remains unclear. “One phenomenon that is known...

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At the Lab: Catch me if you cancer

Communications Department — Tue, 03 Jun 2025 11:30:16 +0000

Earlier this year, one ��ϳԹ��Դ discovery ended up on FOX TV and the cover of Newsday. Now, hear more about the knowledge gaps that make this discovery so crucial and the noble goals that fuel this work in the first place.

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At the Lab: A vitamin for prostate cancer

Communications Department — Tue, 08 Apr 2025 11:30:45 +0000

What if there were a vitamin that could help treat or prevent prostate cancer? This question has been asked before, with unsettling results. For the Season 2 premiere of our podcast, we sat down At the Lab with CSHL Professor Lloyd Trotman to find out about new preclinical studies that could point to a major...

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Are pro-oxidants anti-prostate cancer?

Communications Department — Tue, 07 Jan 2025 12:30:38 +0000

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Vitamin K supplement slows prostate cancer in mice

Jen A. Miller — Thu, 24 Oct 2024 18:00:34 +0000

Science, shows that menadione significantly slows prostate cancer growth in mice and in human-derived cancer cells, as seen here." data-description="" />Prostate cancer is a quiet killer. In most men, it’s treatable. However, in some cases, it resists all known therapies and turns extremely deadly. A new discovery at ��ϳԹ��Դ (CSHL) points to a potentially groundbreaking solution. CSHL Professor Lloyd Trotman’s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression...

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A century of women’s health breakthroughs

Jen A. Miller — Mon, 22 Jul 2024 11:30:17 +0000

Today, there’s a huge movement touting the benefits of breastfeeding over formula feeding. Doctors say breastmilk gives infants better versions of the nutrients critical for brain development. They even say nursing helps reinforce instinctual bonds between mother and child. Some of these claims are largely intuitive. However, much of what we know today about maternal...

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A link between breast changes and . . . UTIs?

Jennifer Michalowski — Thu, 02 May 2024 11:30:55 +0000

Women’s health is often talked about in terms of major, life-altering events like pregnancy and menopause. A new study from ��ϳԹ��Դ (CSHL) underscores the importance of considering everyday occurrences’ impact on women’s well-being. CSHL researchers have made a surprising discovery involving urinary tract infections (UTIs). The scientists found that UTIs in mice...

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New antibody could target breast cancers

Jennifer Michalowski — Mon, 30 Oct 2023 11:30:29 +0000

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of ��ϳԹ��Դ Professor Nicholas Tonks. With further development, the antibody might offer an effective drug treatment for those same breast cancers. The new antibody targets an enzyme called PTPRD that is overabundant in...

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Can our own immune system fight off cancer?

Communications Department — Wed, 10 Nov 2021 20:00:54 +0000

« Previous Story Next Story » One day in 2010, when oncologist Paul Muizelaar operated on a patient with glioblastoma—a brain tumor infamous for its deathly toll—he did something shocking. First, he cut the skull open and carved out as much of the tumor as he could. But before he replaced the piece of skull...

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Why pancreatic ductal adenocarcinoma is so lethal

Communications Department — Tue, 19 May 2020 13:28:31 +0000

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues. This understanding could lead to new...

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Turning off the immune system is hard. Turning it on against cancer is easier.

Andrea Alfano — Wed, 10 Jan 2018 21:14:38 +0000

he immune system’s awesome power has captivated Professor Douglas Fearon throughout over 45 years of study, both as a medical doctor and as a scientist. Yet just 10 years ago, he “didn’t believe in cancer immunology,” he admits frankly. Today, cancer drugs based on the idea of harnessing the immune system’s power are helping to...

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Three Strohm Sisters Family Foundation donates $5,000 for research on lung cancer recurrence

Jill Stone — Mon, 08 Jan 2018 23:44:31 +0000

On December 18, 2017, Ed Strohm of the Three Strohm Sisters Family Foundation presented CSHL Associate Professor Mikala Egeblad with a check for $5,000 to support her ongoing lung cancer research. This is the first donation ��ϳԹ��Դ has received from the Long Island-based foundation, which is dedicated to the eradication of cancer....

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One experiment: Bacteria-trapping DNA webs are repurposed by cancer cells

Peter Tarr — Thu, 19 Oct 2017 19:50:43 +0000

Cancer is infamous for repurposing molecules and mechanisms our body routinely uses to sustain itself. This remarkable 3D image, made by CSHL’s expert electron microscopist Stephen Hearn, dramatically captures one such mechanism, spiderweb-like structures made of DNA and studded with toxic enzymes. Normally, these webs are cast out into extracellular space by white blood cells...

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Halfway around the world, a reunion of friends opens door to a cancer discovery

Andrea Alfano — Thu, 31 Aug 2017 17:43:40 +0000

fter interviewing for a position in a pancreatic cancer lab at ��ϳԹ��Դ, 7,000 miles from his hometown in South Korea, Chang-il Hwang did what many of us would: he posted about it on Facebook. Little did he know that he was rekindling a friendship that would pave the way to a long-sought...

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Long-sought mechanism of metastasis is discovered in pancreatic cancer

Peter Tarr — Thu, 27 Jul 2017 12:00:20 +0000

An epigenetic factor reprograms gene enhancers, enabling cancer cells to “remember” an earlier developmental state Cold Spring Harbor, NY — Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power...

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Newly discovered mutations impair key cell pathways in pancreatic cancer

Peter Tarr — Mon, 08 May 2017 11:00:41 +0000

Cold Spring Harbor, NY — By closely studying a part of the human genome that has not yet been carefully scrutinized in studies of cancer, researchers at ��ϳԹ��Դ (CSHL) have found important new clues to the development of pancreatic cancer. The researchers looked exclusively at small segments of DNA called promoters in...

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Pershing Square Sohn cancer research prize awarded to CSHL’s Dr. Mikala Egeblad

Communications Department — Mon, 08 May 2017 09:00:30 +0000

New York City and Cold Spring Harbor, NY — ��ϳԹ��Դ (CSHL) Associate Professor Mikala Egeblad, Ph.D., has been awarded the Pershing Square Sohn Prize for Young Investigators in Cancer Research. The announcement was made today by The Pershing Square Sohn Cancer Research Alliance. This is the fourth year the Alliance has awarded the...

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Alexa DeAngelis didn’t see a place for herself in science, so she’s making one

Andrea Alfano — Fri, 28 Apr 2017 19:48:56 +0000

For Alexa DeAngelis, who was recently awarded a Fulbright scholarship, combining a desire to help people with a passion for biochemistry means designing her own position in the budding specialty of precision medicine. ust a few weeks into her freshman year as a pre-med student at Georgetown, Alexa DeAngelis went through what she calls a...

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New research explains why even targeted therapies eventually fail in lung cancer

Peter Tarr — Wed, 29 Mar 2017 12:00:49 +0000

Cold Spring Harbor, NY — Nearly 50 years into the “war” on cancer, doctors possess weapons that once would have seemed magical in their tumor-killing specificity. The drug Tarceva (erlotinib), for example, can virtually erase all traces of aggressive lung cancer tumors in a subset of patients who bear a particular disease-driving mutation in a...

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Discovery of distinct cell subtypes around tumors helps explain why pancreatic cancer is so hard to treat

Peter Tarr — Thu, 23 Feb 2017 09:00:16 +0000

Cold Spring Harbor, NY — Researchers have moved an important step closer to understanding why pancreatic cancer is so hard to treat. With a median survival of only 6 months and a 5-year survival rate of about 8%, patients tend to be diagnosed when the disease has already spread to other parts of the body—this...

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cellular communication in cancer Archives | ���ϳԹ���Դ