cancer treatment Archives | ��ϳԹ��Դ

Aspiring physician-scientist to investigate glioblastoma

Communications Department — Wed, 17 Jun 2026 16:00:44 +0000

In a statement, Northwell Health announced that Ethan Ertel, an M.D./Ph.D. student from the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, will join ��ϳԹ��Դ (CSHL) and Northwell teams researching glioblastoma. Ertel will contribute to collaborative laboratory research overseen by CSHL Professor Alea Mills and Northwell’s John Boockvar. The graduate student...

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CSHL develops endometrial cancer organoid platform

Nick Wurm — Thu, 26 Mar 2026 13:00:21 +0000

More than 68,000 women will be diagnosed with endometrial cancer in 2026. More than 14,000 will die from this condition. While some forms of the disease are treatable, high grade endometrial cancer often resists available immunotherapies. “High grade endometrial cancers (HGEC) are very aggressive,” explains ��ϳԹ��Դ Associate Professor Semir Beyaz. “Even when...

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Borniger wins Mark Foundation Emerging Leader Award

Gina Dipietro — Tue, 13 Jan 2026 17:00:17 +0000

��ϳԹ��Դ (CSHL) Associate Professor Jeremy Borniger is among five scientists to receive this year’s Bakewell Emerging Leader Award from The Mark Foundation for Cancer Research. The Award provides Borniger’s lab $750,000 over three years. Borniger’s research explores the potential of synthetic torpor—a hibernation-like metabolic state—as a novel anti-cancer strategy. By suppressing metabolism,...

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Breast cancer case study could inform clinical trials

Jen A. Miller — Mon, 10 Nov 2025 12:30:14 +0000

MALAT1 (pink) than the surrounding tissues." data-description="Fluorescent microscopy image showing clusters of blue and purple cells on a black background." />When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer’s development or spread. Researchers at ��ϳԹ��Դ (CSHL) have also been working on another kind of target. They’re studying a long non-coding RNA called...

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Breast cancer discovery could help prevent recurrence

Margaret Osborne — Mon, 20 Oct 2025 11:30:07 +0000

Know someone who’s been diagnosed with breast cancer? There’s a good chance that person has received hormone therapy. Estrogen receptor-positive (ER+) breast cancers account for about 75 percent of cases. Hormone therapy is one of the most common and effective treatments. However, it’s far from a cure. Some ER+ tumors develop resistance. Many patients enter...

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The journey: One lab’s long winding road to cancer discovery

Margaret Osborne — Wed, 15 Oct 2025 11:30:59 +0000

As many as one in eight men in America will be diagnosed with prostate cancer at some point in their lives. About one in 44 will die from it. “Prostate cancer is very common,” ��ϳԹ��Դ (CSHL) Professor Lloyd Trotman says. “The vast majority of prostate cancers remain slow-growing and will never be...

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Why does cancer keep growing?

Jen A. Miller — Fri, 10 Oct 2025 11:30:24 +0000

Why do cancer cells keep dividing over and over? The answer can be found in fundamental biology breakthroughs of the late 20th century. In 1982, ��ϳԹ��Դ (CSHL) geneticist Michael Wigler helped identify the first known human oncogenes. When mutated, these genes produce an excess of proteins that cause uncontrolled cell growth. Soon...

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Ever use cortisone? Thank one farmer and two CSHL scientists

Jen A. Miller — Wed, 20 Aug 2025 13:00:16 +0000

Addison’s disease is no walk in the park. The disorder occurs when a person’s adrenal glands don’t make enough cortisol. This hormone plays a key role in multiple bodily functions, including metabolism and immune response. People with Addison’s disease can feel fatigued or nauseous, suffer from chronic pain, and lose unhealthy amounts of weight. If...

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Inspiring breast cancer breakthroughs

Communications Department — Mon, 18 Aug 2025 17:30:23 +0000

Breast cancer is one of the most common cancers among women in the United States, second only to skin cancer. Thanks to decades of fundamental research, it’s also one of the most curable. However, challenges remain, especially when confronting aggressive varieties like triple-negative breast cancer. ��ϳԹ��Դ (CSHL) has a rich history of...

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BATMAN brings TCR therapy out of the shadows

Nick Wurm — Fri, 25 Jul 2025 15:00:02 +0000

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Similarities between cancerous and healthy cells can affect the body’s immune response, causing T cells to attack unintended targets. TCR therapy needs...

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‘The bridge between hope and healing’

Caroline Cosgrove — Wed, 04 Jun 2025 11:30:58 +0000

Tens of millions of people affected by brain cancer, strokes, Alzheimer’s, Parkinson’s, and other neurological diseases share a painful dilemma: a lack of viable therapeutic options. Tantalizingly, one of the biggest treatment obstacles is the very thing that protects the brain from harm: the blood-brain barrier (BBB). While the BBB does a remarkable job of...

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At the Lab: A vitamin for prostate cancer

Communications Department — Tue, 08 Apr 2025 11:30:45 +0000

What if there were a vitamin that could help treat or prevent prostate cancer? This question has been asked before, with unsettling results. For the Season 2 premiere of our podcast, we sat down At the Lab with CSHL Professor Lloyd Trotman to find out about new preclinical studies that could point to a major...

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CSHL receives $100K for leukemia research

Nick Wurm — Mon, 24 Feb 2025 12:30:02 +0000

In 1972, 16-year-old Don Monti tragically passed away from acute myeloid leukemia (AML), one of the most aggressive forms of blood cancer. Shortly thereafter, his family founded the Don Monti Memorial Research Foundation (DMMRF) to support research aimed at understanding cancer’s growth and eradicating it from the body. On January 24, the DMMRF donated $100,000...

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Janowitz elected to ASCI

Samuel Diamond — Mon, 27 Jan 2025 12:30:34 +0000

��ϳԹ��Դ Associate Professor Tobias Janowitz has been elected to the American Society for Clinical Investigation (ASCI). Janowitz is recognized for his outstanding scholarly research, which approaches cancer from a whole-body perspective. He has led clinical trials and published authoritative studies on cancer cachexia, a debilitating condition that affects patients in the late...

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From trading faxes to changing lives

Jen A. Miller — Tue, 14 Jan 2025 17:00:40 +0000

Sometimes, scientific breakthroughs happen by accident. Penicillin was discovered when a British scientist left a petri dish uncovered while he was away on vacation. Other times, serendipity plays a role. Case in point: two chance meetings at ��ϳԹ��Դ (CSHL) led to the development of a drug that has vastly improved patient outcomes for...

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Are pro-oxidants anti-prostate cancer?

Communications Department — Tue, 07 Jan 2025 12:30:38 +0000

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Vitamin K supplement slows prostate cancer in mice

Jen A. Miller — Thu, 24 Oct 2024 18:00:34 +0000

Science, shows that menadione significantly slows prostate cancer growth in mice and in human-derived cancer cells, as seen here." data-description="" />Prostate cancer is a quiet killer. In most men, it’s treatable. However, in some cases, it resists all known therapies and turns extremely deadly. A new discovery at ��ϳԹ��Դ (CSHL) points to a potentially groundbreaking solution. CSHL Professor Lloyd Trotman’s lab has found that the pro-oxidant supplement menadione slows prostate cancer progression...

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At the Lab Season 1 Research Rewind: Cancer

Communications Department — Tue, 08 Oct 2024 11:30:26 +0000

Miss an episode or two from the first season of our new podcast? Over the next few weeks, we’ll revisit each in a series we call ‘Research Rewind.’ This week At the Lab, you’ll hear all about our cutting-edge cancer research from CSHL scientists Semir Beyaz, Mikala Egeblad, Alea Mills, John Moses, and Christopher Vakoc....

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Old chemo drug, new pancreatic cancer therapy?

Nick Wurm — Mon, 26 Aug 2024 11:30:57 +0000

The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in...

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How to stop cancer cachexia? Start at the top

Nick Wurm — Mon, 08 Jul 2024 11:30:11 +0000

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes—like the body’s immune response—to grow and spread. When tumors elevate levels of an immune system molecule called Interleukin-6 (IL-6), it can cause severe brain dysfunction. In about 50%-80% of cancer patients, this leads to a lethal wasting disease called cachexia. “It’s a...

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