cancer biology Archives | ��ϳԹ��Դ

On the trail of a cellular cold case

Nick Wurm — Tue, 16 Dec 2025 17:00:43 +0000

If you remember high school biology, you know cells pack a lot inside a tiny package. Inside the nucleus of every one of our cells, you’ll see more than a few things floating around. You may be familiar with RNA and DNA. But that’s not all you’ll find there. Over a century ago, scientists discovered...

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Why does cancer keep growing?

Jen A. Miller — Fri, 10 Oct 2025 11:30:24 +0000

Why do cancer cells keep dividing over and over? The answer can be found in fundamental biology breakthroughs of the late 20th century. In 1982, ��ϳԹ��Դ (CSHL) geneticist Michael Wigler helped identify the first known human oncogenes. When mutated, these genes produce an excess of proteins that cause uncontrolled cell growth. Soon...

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Go inside cancer’s biology

Nick Wurm — Mon, 22 Sep 2025 16:00:16 +0000

What happens inside and around a cancer cell? How does a tumor’s interaction with its surroundings contribute to cancer’s growth and spread? These questions could lead to a new generation of cancer therapies with fewer harmful side effects. Appropriately, they’re being asked and answered by a new generation of scientists at forums like the Cold...

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A speckle of hope for cancer patients

Luis Sandoval — Thu, 02 Jan 2025 10:00:42 +0000

Nature Cell Biology. " data-description="" />AI generated voice with Kate Alexander’s actual voice Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, ��ϳԹ��Դ (CSHL) Assistant Professor Katherine Alexander and University of...

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At the Lab Season 1 Research Rewind: Cancer

Communications Department — Tue, 08 Oct 2024 11:30:26 +0000

Miss an episode or two from the first season of our new podcast? Over the next few weeks, we’ll revisit each in a series we call ‘Research Rewind.’ This week At the Lab, you’ll hear all about our cutting-edge cancer research from CSHL scientists Semir Beyaz, Mikala Egeblad, Alea Mills, John Moses, and Christopher Vakoc....

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How breast cancer goes hungry

Jennifer Michalowski — Wed, 28 Aug 2024 11:30:11 +0000

Cancer cells have voracious appetites. And there are certain nutrients they can’t live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells’ diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their...

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How diet may impact cancer and possible treatments

Margaret Osborne — Thu, 01 Feb 2024 12:30:30 +0000

About 10 million people die every year of cancer. It’s the second leading cause of death in the U.S., behind heart disease, with more than 1,500 fatalities here each day. Yet, much about it remains unknown. Researchers have linked some behaviors to a higher risk of developing the disease. People who smoke, for example, tend...

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From cancer genetics to cancer treatments

Jen A. Miller — Thu, 18 Jan 2024 12:30:49 +0000

What is cancer? How does it develop and spread? And how do we stop it? Thanks to science, today’s doctors can better answer all of these questions. That’s not because of one eureka moment. Instead, it’s the result of thousands of discoveries that built upon each other. Case in point: two of the most important...

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Metastatic breast cancer’s Trojan horse

Nick Wurm — Wed, 26 Jul 2023 11:30:34 +0000

Lymph nodes are one of the body’s first lines of defense against disease. Immune cells are dispatched from these biological police stations to fight off intruders. But somehow, lymph nodes are also the first stop for most metastatic cancers. “It’s paradoxical,” ��ϳԹ��Դ (CSHL) Assistant Professor Semir Beyaz says. “The cancer goes right...

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Humans of Banbury: Interview with Marcus Goncalves

Jenna Jacobs — Wed, 31 May 2023 15:24:02 +0000

In March 2023, the Banbury Center welcomed experts for “The Future of Investigational Medicine: Utilizing Science to Optimize the Early Phase Oncology Clinical Trial Effort.” During the meeting, I had the opportunity to sit down with Marcus Goncalves, M.D., Ph.D. Dr. Goncalves is an endocrinologist and laboratory scientist at Weill Cornell Medicine. He received his...

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Identifying cancer genes’ multiple personalities

Margaret Osborne — Mon, 10 Apr 2023 11:30:01 +0000

Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex. Mutations in the same genes can lead to different subtypes of tumors in different people. Currently, scientists don’t have a good way to produce such tumor subtypes for study in the lab. Now, Cold Spring Harbor...

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Targeting cancer’s Achilles heel

Communications Department — Fri, 04 Nov 2022 11:30:01 +0000

« Previous Story Next Story » Matthew Weiss dreams of the day when his oncology practice will operate very differently. A surgeon at the Northwell Health System in New York who treats pancreatic cancer—one of the deadliest malignancies known—he doesn’t have a lot of choices when it comes to saving his patients. Some people with...

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Cancer has a lot of nerve

Communications Department — Mon, 22 Aug 2022 11:30:51 +0000

« Previous Story Next Story » Manish Vira, a urologist at Northwell Health in New York performs prostate biopsy procedures three to five times a week. He inserts 12 needles into the prostate gland in specific locations, identified by MRI images that reveal malignant or suspicious lesions. The samples then go to a pathologist who...

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Copper, cancer, and COVID-19: The story of an idea, a meeting, and a paper

Hannah Stewart — Fri, 04 Mar 2022 17:00:27 +0000

Where does a scientific review article begin? How does an idea evolve from a thought to a published paper? Sometimes, a Banbury meeting helps the process along. Two years ago this week, the Banbury Center convened the Copper Cancer Consortium to discuss the importance of copper in biological functions such as angiogenesis, mitochondrial respiration, and...

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Obscure protein is spotlighted in fight against leukemia

Jasmine Lee — Tue, 11 Jan 2022 16:00:10 +0000

Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. ��ϳԹ��Դ (CSHL) Professor Christopher Vakoc and former graduate student Sofya Polyanskaya found that AML cells rely on a previously little-known protein called SCP4 for survival. Their discovery points to a potential...

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Corina Amor joins CSHL faculty

Jasmine Lee — Fri, 07 Jan 2022 12:30:27 +0000

��ϳԹ��Դ (CSHL) is pleased to welcome Corina Amor to the faculty as a CSHL fellow. Amor’s current work is focused on senescent (aging) cells. As senescent cells accumulate, they can lead to age-related diseases like cancer. She studies how aging cells are able to evade the immune system and what kinds of...

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Exploiting cancer’s sweet tooth

Jasmine Lee — Mon, 25 Oct 2021 10:30:46 +0000

Inositol is a sugar required for cells to survive. Most cells either get it from the bloodstream or make it themselves. Since there is plenty of inositol available, some cancer cells decide to stop making it. ��ϳԹ��Դ Professor Christopher Vakoc and his lab discovered that acute myeloid leukemia (AML), an aggressive cancer...

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Mestag, co-founded by CSHL prof, named leading new biotech

Jasmine Lee — Mon, 27 Sep 2021 12:30:48 +0000

Fierce Biotech named Mestag Therapeutics™, a start-up inflammatory disease and immuno-oncology company, as one of its 2021 “Fierce 15” biotechnology companies. Mestag was founded in 2020 by an international team of researchers including ��ϳԹ��Դ (CSHL) Professor and Cancer Center Director David Tuveson. Mestag is developing new therapeutics for people affected by inflammatory...

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How pancreatic cancer cells dodge drug treatments

Luis Sandoval — Tue, 22 Jun 2021 13:15:49 +0000

KRAS gene that allow unregulated growth. In this image, the mutant, cancer-causing version of the KRAS protein is stained red in pancreatic cancer cells. KRAS outlines the plasma membrane—the outer layer of the cell. Cell nuclei are stained blue. ��ϳԹ��Դ researchers discovered a new mechanism that might explain how pancreatic cancer cells develop resistance to drug treatments that target the KRAS protein. Image: Derek Cheng/Tuveson lab " data-description="" />Cancer cells can become resistant to treatments through adaptation, making them notoriously tricky to defeat and highly lethal. ��ϳԹ��Դ (CSHL) Cancer Center Director David Tuveson and his team investigated the basis of “adaptive resistance” common to pancreatic cancer. They discovered one of the backups to which these cells switch when confronted with...

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$11 million investment to develop fibroblast therapeutic

Communications Department — Mon, 26 Apr 2021 12:30:21 +0000

Mestag Therapeutics™, a new company developing innovative therapies and treatments for cancers and inflammatory diseases, has been launched with $11 million in seed financing. In collaboration with ��ϳԹ��Դ (CSHL), Mestag is pursuing a first-in-class therapeutic strategy that focuses on cells called fibroblasts, which can impede the effectiveness of traditional cancer treatments. The...

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cancer biology Archives | ���ϳԹ���Դ