Alzheimer's Archives | ��ϳԹ��Դ

Corina Amor Vegas awarded $750K MIND Prize

Gina Dipietro — Tue, 10 Mar 2026 14:00:20 +0000

��ϳԹ��Դ (CSHL) Assistant Professor Corina Amor Vegas has been named a recipient of the Pershing Square Foundation’s 2026 Maximizing Innovation in Neuroscience Discovery (MIND) Prize. This coveted prize is awarded annually to five to seven early-to-mid-career investigators who dare to challenge conventional thinking around neurodegenerative diseases, including Alzheimer’s disease and dementia, which...

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Researchers find new way to slow memory loss in Alzheimer’s

Gina Dipietro — Thu, 05 Feb 2026 12:30:28 +0000

Alzheimer’s disease is often measured in statistics: millions affected worldwide, cases rising sharply, costs climbing into the trillions. For families, the disease is experienced far more intimately. “It’s a slow bereavement,” says ��ϳԹ��Դ Professor Nicholas Tonks, whose mother lived with Alzheimer’s. “You lose the person piece by piece.” There’s a lot of...

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A doorstop for the brain’s electrical gates

Jennifer Michalowski — Wed, 29 Oct 2025 16:00:04 +0000

Nature, reveals the molecular mechanisms that keep the brain’s NMDA receptors fully or partially open." data-description="Image of NMDA receptors in different positions" />As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At ��ϳԹ��Դ (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell—and the molecular gatekeepers that help control them. CSHL structural biologist Hiro Furukawa studies NMDA receptors (NMDARs). These...

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Mind-blowing neuroscience research

Communications Department — Tue, 22 Jul 2025 11:30:19 +0000

The brain is the most complex and powerful part of the human body. When things are working as they should, we don’t notice at all. However, any number of conditions can disrupt healthy brain function. ��ϳԹ��Դ (CSHL) neuroscientists focus on understanding how neural connections in the brain translate into behavior. Their research...

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A CSHL Symposium for the ages

Samuel Diamond — Thu, 05 Jun 2025 11:30:05 +0000

You are not the same person you were a decade ago. Most of your body’s cells are replaced every seven to 10 years. Nevertheless, you retain the genes and memories that help make you, you. Science still doesn’t fully understand how the aging process works. But we’re getting closer, and the answers may hold the...

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‘The bridge between hope and healing’

Caroline Cosgrove — Wed, 04 Jun 2025 11:30:58 +0000

Tens of millions of people affected by brain cancer, strokes, Alzheimer’s, Parkinson’s, and other neurological diseases share a painful dilemma: a lack of viable therapeutic options. Tantalizingly, one of the biggest treatment obstacles is the very thing that protects the brain from harm: the blood-brain barrier (BBB). While the BBB does a remarkable job of...

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Cocktails & Chromosomes: Hormones on my mind

Communications Department — Wed, 09 Apr 2025 11:30:14 +0000

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Lucas Cheadle awarded $750K MIND Prize

Samuel Diamond — Tue, 01 Apr 2025 14:00:05 +0000

As the world’s population ages, neurodegenerative conditions like Alzheimer’s disease are becoming more and more common. Alzheimer’s is the leading cause of dementia. And though research into these conditions has yielded many fascinating results, few have translated to clinical applications. Today, we have a better idea of what Alzheimer’s does to the brain. However, we’re...

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At the Lab Season 1 Research Rewind: Neuroscience

Communications Department — Tue, 15 Oct 2024 11:30:25 +0000

Trying to remember that one thing that one CSHL scientist said about the brain that one time? Jog your memory and catch up on what you might have missed in our latest Research Rewind. This week At the Lab, you’ll hear all about our innovative neuroscience research from CSHL scientists Arkarup Banerjee, Benjamin Cowley, Hiro...

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One Experiment: The brain’s landscapers

Nick Wurm — Thu, 10 Oct 2024 11:30:04 +0000

Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze. What you see might look something like the above image from ��ϳԹ��Դ’s (CSHL’s) Cheadle lab. But those purple and...

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This protein does “The Twist”

Luis Sandoval — Wed, 31 Jul 2024 15:00:56 +0000

Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These...

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At the Lab Episode 2: Molecular puppetry

Communications Department — Tue, 09 Apr 2024 11:30:36 +0000

It’s easy to think of your brain as your body’s puppet master. This week At the Lab, we speak with CSHL Professor Hiro Furukawa, who studies a part of the brain that actually does work a lot like a puppeteer. Hear how Furukawa figured out the puppet master’s routine. And find out what that might...

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Foundations for the Future: Blueprint for tomorrow

Communications Department — Mon, 13 Nov 2023 12:30:00 +0000

Welcome to ��ϳԹ��Դ (CSHL), where innovation meets the future. Join us as we embark on a journey into the heart of our audacious $500 million capital campaign, Foundations for the Future. At the core of this ambitious endeavor lies a visionary seven-acre expansion dedicated to pioneering research in three critical areas that...

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This eight-armed octopus-like pore perceives taste

Jennifer Michalowski — Fri, 14 Jul 2023 11:30:33 +0000

The neurons in our bodies are dotted with tiny pores that let essential molecules pass in and out of our cells. Neurons need these channels to send the signals that allow us to move, think, and perceive the world around us. Now, structural biologists at ��ϳԹ��Դ (CSHL) have captured never-before-seen images of...

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A new look at brain function and psychiatric disorders

Jennifer Michalowski — Wed, 02 Nov 2022 11:30:23 +0000

New images from scientists at ��ϳԹ��Դ (CSHL) reveal for the first time the three-dimensional structures of a set of molecules critical for healthy brain function. The molecules are members of a family of proteins in the brain known as NMDA receptors, which mediate the passage of essential signals between neurons. The detailed...

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Mapping brain disorder therapeutics at work

Communications Department — Fri, 29 Jul 2022 16:00:19 +0000

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Mapping out new routes to treat brain disorders

Daniel Dunaief — Fri, 10 Jun 2022 14:00:01 +0000

��ϳԹ��Դ (CSHL) Professor Hiro Furukawa takes an architectural approach to brain research. He creates structural 3D maps of important proteins that malfunction in brain disorders. Furukawa has zeroed in on a protein called the NMDA (for N-methyl-D-aspartate) receptor that plays a key role in learning and memory. The NMDA receptor acts as...

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Picky proteins: A new angle for brain disorder therapeutics

Communications Department — Fri, 20 May 2022 11:30:48 +0000

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Brain receptor pulls open electrical gate like a puppet master

Communications Department — Tue, 30 Jun 2020 15:09:08 +0000

For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals. Critical for brain development and function, the receptor converts chemical messages between cells into electrical signals within a neuron. The...

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New look at odd holes involved in taste, Alzheimer’s, asthma

Brian Stallard — Mon, 27 Jan 2020 16:00:39 +0000

Many cells are covered with mysterious large holes, pores that have been associated with the sense of taste as well as Alzheimer’s disease, depression, and even asthma. Knowing the structure of these varied holes will help researchers better understand this range of associations and provide a blueprint for developing new therapies. “One of the most...

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